Furthermore, detection of minimal residual disease is important for prognosis determination and treatment planning, and it has. The first consensus guideline was published in 2003 and the first annual brainstorming summit was organized in barcelona in 2010. Treatment of multiple myeloma has substantially changed over the past decade with the introduction of several classes of new effective drugs that have greatly improved the rates and depth of response. Table 1, below, outlines the revised imwg criteria for the diagnosis of myeloma. Kastritis et al greek group 2014 identified 965 14% of patients with smouldering myeloma to have 1 focal lesion on spinal mri and the median time to progression for this group was 15 months, with 69% of patients progressing by 2 years and 85% by 3 years. Mar 15, 2017 in november 2014, the international myeloma working group imwg revised the diagnostic criteria for several reasons. International myeloma working group recommendations for the. Imwg updated criteria for the diagnosis of myeloma academy. International myeloma working group updated criteria for. International myeloma working group consensus criteria for.
New diagnostic criteria for multiple myeloma clinical. Biopsyproven solitary lesion of bone or soft tissue with evidence. Plasmacytoma bone lesion extramedullary soft tissue plasmacytoma. Kyle r, child ja, anderson k, barlogie b, bataille r, bensinger w, et al. Updated diagnostic criteria and staging system for multiple. In 2014, the international myeloma working group revised the diagnostic criteria for multiple myeloma. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any di.
Multiple myeloma mm has been traditionally defined by the presence of endorgan damage, specifically, hypercalcemia, renal failure, anemia, and bone lesions crab features that are felt to be a consequence of the underlying clonal plasma cell proliferation. International myeloma working group research collaboration. Table 3 diagnostic criteria diagnosis diagnostic criteria. Guideline rajkumar sv, dimopoulos ma, palumbo a, et al. The diagnostic and response criteria recommended are primarily derived from the international myeloma working group, with certain updates and clarifications. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any differences in outcome that might occur as a result of the new disease definition.
The international staging system is the current standard for staging of myeloma. International myeloma working group diagnostic criteria for multiple myeloma and related plasma cell disorders disorder disease definition nonigm monoclonal gammopathy of undetermined significance mgus all 3 criteria must be met. The diagnostic criteria for multiple myeloma and related disorders have been updated by the international myeloma working group. It became clear that there was a need to conduct collaborative research and produce consensus guidelines for the myeloma community. The updated criteria for the diagnosis of myeloma represent a paradigm shift in the approach to myeloma and have considerable impact on the management of the disease. Imwg updated criteria for the diagnosis of myeloma this paper, produced by an expert panel of the international myeloma working group imwg, provides consensus updates on the disease definition of myeloma which now include validated biomarkers in addition to the presence of the traditional crab criteria. The international myeloma working group imwg emerged from the imfs scientific advisory board which was established in 1995. The international myeloma working group established the below criteria in order to. Mar 14, 2016 purpose the aim of the international myeloma working group was to develop practical recommendations for the diagnosis and management of multiple myelomarelated renal impairment ri. Theses recommendations are excerpted from palumbo a et. Risk stratification of smoldering multiple myeloma.
Apr 25, 2018 in 2014, the international myeloma working group imwg panel consensus 1 updated 2003 criteria for the diagnosis of multiple myeloma by adding three new biomarkers, along with a few other modifications. International myeloma working group imwg criteria for the diagnosis of multiple myeloma. International myeloma working group diagnostic criteria for multiple myeloma and related plasma cell disorders disorder disease definition nonigm mgus all three criteria must be met. International myeloma working group imwg offshoot of international myeloma foundation. What are the imwg diagnostic criteria for multiple myeloma. Serum monoclonal protein nonigm type, 3 gdl clonal bone marrow plasma cells, 10%. The international myeloma working group recommends the implementation of these criteria in routine practice and in future clinical trials, and recommends that future studies analyse any diff erences in outcome that might occur as a result of the new disease defi nition. Multiple myeloma the path to diagnosis mymyelomateam. These changes are based on the identification of biomarkers associated with near inevitable development of crab features in patients. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders.
This international myeloma working group consensus updates the disease definition of multiple myeloma to include validated biomarkers in addition to existing requirements of attributable crab features hypercalcaemia, renal failure, anaemia, and bone lesions. Develop guidelines for diagnosis, management, response criteria, etc. Guidelines for serum free light chain analysis in multiple myeloma and related disorders 2009 25. In 2014, the international myeloma working group imwg panel consensus 1 updated 2003 criteria for the diagnosis of multiple myeloma by adding three new biomarkers, along with a few other modifications. Methods recommendations were based on published data through december 2015, and were developed using the system developed by the grading of recommendation, assessment, development, and evaluation working group. Jul 20, 2006 the international myeloma working group has developed new standard diagnostic criteria 8 and a new international staging system iss for multiple myeloma, 9 which are being widely accepted as the.
International myeloma working group guidelines for the. International myeloma working group consensus approach to the. Serum monoclonal protein nonigm type 200 leading myeloma researchers. Updated international myeloma working group criteria. The international myeloma working group imwg and mayo clinic have established almost identical criteria for the diagnosis of the plasma cell proliferative disorders. In 2003, the international myeloma working group imwg announced a consensus on diagnostic criteria for classifying and differentiating plasma cell pc proliferative disorders including symm. The revised international myeloma working group criteria for the diagnosis of multiple myeloma and related disorders are shown on table 1. Revised international myeloma working group imwg criteria. According to the revised international myeloma working group, diagnostic criteria for multiple myeloma include one of these major signs, confirmed by a bone marrow biopsy. The revised imwg diagnostic criteria for smm and mm are listed in table 2. Imwg criteria for the diagnosis of myeloma and guidelines for. New systems have emerged for diagnosis, staging and response assessment in multiple myeloma mm. For a diagnosis of sp, the international myeloma working group imwg requires all four of the following criteria be metref1. The present disease definitions of smouldering multiple myeloma and multiple myeloma were reported by the international myeloma working group imwg in 2003.
The international myeloma working group imwg recently updated the diagnostic criteria for myeloma to include biomarkers, in addition to the existing crab features. The detection of bone and bone marrow lesions is crucial in the investigation of multiple myeloma and often dictates the decision to start treatment. International uniform response criteria for multiple myeloma. These new criteria add myeloma defining events, the presence of any one of. International myeloma working group imwg criteria for the. International myeloma working group guidelines wikilite. The diagnosis of multiple myeloma requires the presence of one or more myeloma defining events mde in addition to evidence of either. Aug 16, 2018 the revised international myeloma working group criteria for the diagnosis of multiple myeloma and related disorders are shown on table 1. Consensus guidelines on the diagnosis of multiple myeloma and. Recent advances in the treatment of multiple myeloma have increased the need for accurate diagnosis of the disease. Consensus statement on diagnostic requirements, response criteria and treatment recommendations by the international myeloma working group november 2012. International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders. Introduction multiple myeloma is a cytogenetically heterogeneous. Imwg criteria for the diagnosis of myeloma and guidelines for the diagnostic workup of myeloma criteria for a diagnosis of myeloma followed by the examinations, tests, and imaging studies that are recommended by the working group for the diagnosis of myeloma and related organ dysfunction.
Patients with 60% or more clonal plasma cell involvement of the marrow, serum free light chain ratio of 100 or higher provided involved free light chain level. International myeloma working group updated criteria for the. Overall, only 35% of the patients are younger than 65 years at the time of diagnosis, whereas the remaining twothirds are older. The revised international myeloma working group criteria for the diagnosis of multiple myeloma and related disorders are shown on table i 1. The international myeloma working group imwg has updated the diagnostic criteria for mm in 2014, adding 3 specific biomarkers that. Criteria for diagnosis, staging, risk stratification and. International myeloma working group updated criteria for the diagnosis of multiple myeloma. New diagnostic criteria for myeloma nssg haematology. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Response criteria in multiple myeloma were developed to use serum and urine assessment of monoclonal proteins and bone marrow assessment which is relatively insensitive.